Thiocolchicine
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Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of... more
Product information "Thiocolchicine"
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine (Cay-9000760). It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).Formal Name: N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide. CAS Number: 2730-71-4. Synonyms: NSC 186301. Molecular Formula: C22H25NO5S. Formula Weight: 415.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. lambdamax: 230, 254, 288, 379 nm. SMILES: O=C1C(SC)=CC=C2C([C@@H](NC(C)=O)CCC3=C2C(OC)=C(OC)C(OC)=C3)=C1. InChi Code: InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1. InChi Key: CMEGANPVAXDBPL-INIZCTEOSA-N.
| Keywords: | NSC 186301, N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 17427 |
Properties
| Application: | Tubulin polymerization inhibitor, Topo I inhibitor, apoptosis inducer |
| MW: | 415.5 D |
| Formula: | C22H25NO5S |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 2730-71-4| Matching products |
| KEGG ID : | K07374 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H300, H318, H330, H340 |
| P Phrases: | P201, P202, P260, P264, P270, P271, P280, P284, P320, P321, P330, P301+P310, P304+P340, P305+P351+P338, P308+P313, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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