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Thiabendazole is a broad-spectrum anthelmintic that is active against a variety of helminths. In sheep, thiabendazole (50 mg/kg) kills greater than 95% of adult worms from ten genera, including Trichostrongylus, Cooperia, Nematodirus, Ostertagia, Haemonchus, Oesophagostomum, Bunostomum, Strongyloides, Chabertia, and Trichuris. It also inhibits production of eggs and disrupts larval development. Thiabendazole inhibits fumarate reductase in helminths, which inhibits succinate formation, and therefore energy production through the citric acid cycle. It also inhibits methionine aminopeptidase in E. coli (Ki = 40 nM, IC50 = 47.2 nM). Formulations containing thiabendazole have been used in the control of parasitic infections in livestock.Formal Name: 2-(4-thiazolyl)-1H-benzimidazole. CAS Number: 148-79-8. Synonyms: NSC 90507, NSC 525040, TBZ, Tiabendazole. Molecular Formula: C10H7N3S. Formula Weight: 201.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 243, 301 nm. SMILES: C12=CC=CC=C1NC(C3=CSC=N3)=N2. InChi Code: InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13). InChi Key: WJCNZQLZVWNLKY-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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