Tenovin-6

Tenovin-6
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13086-1 1 mg -

6 - 10 business days*

164.00€
Cay13086-5 5 mg -

6 - 10 business days*

738.00€
Cay13086-10 10 mg -

6 - 10 business days*

1,310.00€
Cay13086-25 25 mg -

6 - 10 business days*

2,867.00€
 
The tumor suppressor function of p53 hinges on its ability to function as a transcription factor.... more
Product information "Tenovin-6"
The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 µM, respectively. Formal Name: N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide. CAS Number: 1011557-82-6. Molecular Formula: C25H34N4O2S. Formula Weight: 454.6. Purity: >95%. Formulation: A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 1 mg/ml. SMILES: CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(CCCCN(C)C)=O)C=C2)=S)=O)C=C1. InChi Code: InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32). InChi Key: BVJSXSQRIUSRCO-UHFFFAOYSA-N.
Keywords: N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 13086

Properties

Application: SIRT inhibitor
MW: 454.6 D
Formula: C25H34N4O2S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 1011557-82-6| Find alternatives
KEGG ID : K11412 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H315, H317, H318, H334, H335, H341, H361, H370, H413
P Phrases: P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P284, P310, P312, P321, P302+P352, P304+P340, P304+P341, P305+P351+P338, P308+P311, P308+P313, P332+P313, P333+P313, P342+P311, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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