Tenovin-1

Tenovin-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13085-5 5 mg -

6 - 10 business days*

33.00€
Cay13085-10 10 mg -

6 - 10 business days*

62.00€
Cay13085-50 50 mg -

6 - 10 business days*

260.00€
Cay13085-100 100 mg -

6 - 10 business days*

455.00€
 
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates... more
Product information "Tenovin-1"
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt's lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family. While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo. Formal Name: N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide. CAS Number: 380315-80-0. Molecular Formula: C20H23N3O2S. Formula Weight: 369.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 0.50 mg/ml, DMSO: 0.25 mg/ml. SMILES: CC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C. InChi Code: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26). InChi Key: WOWJIWFCOPZFGV-UHFFFAOYSA-N.
Keywords: N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 13085

Properties

Application: SIRT inhibitor
MW: 369.5 D
Formula: C20H23N3O2S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 380315-80-0| Find alternatives
KEGG ID : K11411 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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