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Item number: Cay13085-10

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt's lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by...

Keywords:	N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide
Application:	SIRT inhibitor
CAS	380315-80-0
MW:	369.5 D

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Tenovin-1

Item number: LKT-T1852.10

Tenovin-1 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53, sirtuins are considered class III histone deacetylases (HDACs). Tenovin-1 exhibits anticancer potential, increasing FOXO3 and p53 and inducing apoptosis in cutaneous T-cell lymphoma cells.

Application:	SIRT inhibitor
CAS	380315-80-0
MW:	369.48 D

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