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Tenovin-1
Item number: TGM-T1919-100mg
Description: Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. Target: Dehydrogenase, Autophagy, Sirtuin, p53, Mdm2. Smiles: CC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1. References: Lain S, et al. Cancer...
| Keywords: | Tenovin 1 |
| Application: | SIRT inhibitor |
| CAS | 380315-80-0 |
| MW: | 369.48 D |
From 37.00€
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Tenovin-1
Item number: Cay13085-10
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt's lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by...
| Keywords: | N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide |
| Application: | SIRT inhibitor |
| CAS | 380315-80-0 |
| MW: | 369.5 D |
From 45.00€
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Tenovin-1
Item number: LKT-T1852.10
Tenovin-1 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53, sirtuins are considered class III histone deacetylases (HDACs). Tenovin-1 exhibits anticancer potential, increasing FOXO3 and p53 and inducing apoptosis in cutaneous T-cell lymphoma cells.
| Application: | SIRT inhibitor |
| CAS | 380315-80-0 |
| MW: | 369.48 D |
From 109.00€
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