Tefinostat

An inhibitor of HDACs and a prodrug form of CHR-2847, increases intracellular protein acetylation in CD14+ primary human AML cells and gammaH2AX levels in primary CMML cells, selectively inhibits the growth of primary AML cells over normal bone marrow cells at 500 nM, induces beta-oxidation of hexacosanoic acid in primary human macrophages at 2 µM, inhibits the migration of isolated human PBMCs toward supernatant isolated from LPS-stimulated primary human macrophages