TCS-OX2-29

Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.Formal Name: (2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone, monohydrochloride. CAS Number: 1610882-30-8. Molecular Formula: C23H31N3O3 . HCl. Formula Weight: 434.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 286 nm. SMILES: COC1=C(OC)C=C(CN(C([C@H](C(C)(C)C)NCC2=CC=NC=C2)=O)CC3)C3=C1.Cl. InChi Code: InChI=1S/C23H31N3O3.ClH/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26,/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3,1H/t21-,/m1./s1. InChi Key: NHKNHFJTMINMBP-ZMBIFBSDSA-N.