31 products were found matching "K04239"!

[Ala11,D-Leu15]-Orexin B is a synthetic peptide agonist of the orexin 2 (OX2) receptor. It selectively induces calcium mobilization in CHO-K1 cells expressing OX2 over CHO-K1 cells expressing OX1 (EC50s = 0.13 and 52 nM, respectively, for the human receptors). [Ala11,D-Leu15]-Orexin B inhibits forskolin-, PACAP...

Suvorexant (Cay-22911) is an analytical reference standard categorized as a diazepane sedative. Formulations containing suvorexant show abuse potential similar to zolpidem (Cay-15792) in recreational polydrug users with a history of sedative and psychedelic drug use. Suvorexant is regulated as a Schedule IV compound...

JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R). It has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors. Applied subcutaneously to rats, JNJ-10397049 decreases the latency to...

Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: OX2R, HCRTR2 Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: OX2R, HCRTR2 Protein function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. [The UniProt Consortium]

Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay). It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg....

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. Protein function:...

Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered...

MK-1064 is an orexin 2 receptor (OX2R) antagonist that is selective for OX2R over OX1R (IC50s = 18 and 1,789 nM, respectively). It decreases the amount of time spent in active wake and increases the time spent in rapid eye movement (REM) sleep and slow-wave sleep (SMS) in mice, rats, dogs, and rhesus monkeys when...

Orexin 2 receptor agonist is an agonist of the orexin 2 receptor (OX2R) with an EC50 value of 23 nM in a calcium influx assay. It is 70-fold selective for OX2R over OX1R (EC50 = 1,616 nM).Formal Name:...

Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on...