SRT 2183

SRT 2183 is an activator of sirtuin 1 (SIRT1, EC50 = 0.36 µM). However, it was found only to bind fluorophore-labeled SIRT1 and also inhibits 14 targets, including cannabinoid receptor 1 (CB1), adenosine receptor 3 (A3), and phosphodiesterase 5 (PDE5), in a panel of 100 receptors, enzymes, ion channels, and transporters at 10 µM. SRT 2183 (2 µM) inhibits RANKL-induced osteoclastogenesis in primary mouse bone marrow-derived macrophages (BMDMs). It inhibits apoptosis induced by hydrogen peroxide (H2O2) in primary mouse renal medullary interstitial cells when used at a concentration of 5 µM. SMILES O[C@@H](C1)CCN1CC2=CSC3=NC(C4=C(NC(C(C=C5)=CC6=C5C=CC=C6)=O)C=CC=C4)=CN23 InChi Code InChI=1S/C27H24N4O2S/c32-22-11-12-30(15-22)14-21-17-34-27-29-25(16-31(21)27)23-7-3-4-8-24(23)28-26(33)20-10-9-18-5-1-2-6-19(18)13-20/h1-10,13,16-17,22,32H,11-12,14-15H2,(H,28,33)/t22-/m1/s1 InChi Key MUFSINOSQBMSLE-JOCHJYFZSA-N