SRT 1720

A SIRT1 activator (EC1.5 = 0.16 µM in a cell-free fluorescence polarization assay), reduces acetylated p53 levels in U2OS cells at 0.1 µM, reduces fed blood glucose levels, improves insulin sensitivity, and increases mitochondrial capacity in a DIO mouse model of diabetes at 100 mg/kg, improves liver, adipose tissue, and skeletal muscle insulin sensitivity in Zucker fa/fa rats, decreases synovitis and delays osteoarthritis progression in mice at 25 mg/kg. SMILES: O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C4=CN5C(CN6CCNCC6)=CSC5=N4)C=CC=C3. InChi Code: InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33). InChi Key: IASPBORHOMBZMY-UHFFFAOYSA-N