SJ6986

SJ6986 is a degrader of G1 to S phase transition 1 (GSPT1) and GSPT2. It reduces the levels of GSPT1 and GSPT2 in MV4-11 cells in a concentration-dependent manner. SJ6986 inhibits proliferation of MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cells (EC50s = 1.5, 0.4, 726, 336, and 3,583 nM, respectively) and reduces the viability of MV4-11 cells endogenously expressing cereblon but not MV4-11 cereblon knockout cells.Formal Name: N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-benzenesulfonamide. CAS Number: 2765625-93-0. Molecular Formula: C20H14F3N3O7S. Formula Weight: 497.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 237 nm. SMILES: FC(F)(F)OC1=CC=CC=C1S(NC2=CC3=C(C(N(C4C(NC(CC4)=O)=O)C3=O)=O)C=C2)(=O)=O. InChi Code: InChI=1S/C20H14F3N3O7S/c21-20(22,23)33-14-3-1-2-4-15(14)34(31,32)25-10-5-6-11-12(9-10)19(30)26(18(11)29)13-7-8-16(27)24-17(13)28/h1-6,9,13,25H,7-8H2,(H,24,27,28). InChi Key: RKAFYSIKAVFVPS-UHFFFAOYSA-N.