41 products were found matching "K03267"!
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Molecular Glue/PROTAC Optimization Kit for GSPT1
Item number: BPS-83882
The Molecular Glue/PROTAC(R) Optimization Kit for GSPT1 is an AlphaLISA(R) assay designed for the testing and profiling of Molecular Glues (MG) and PROTACs (proteolysis targeting chimera) targeting GSPT1 (G1 to S phase transition 1). The kit comes with enough recombinant GSPT1, biotinylated Cereblon-DDB1 complex,...
| Keywords: | GSPT1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, G1 to S phase transition protein 1 homolog |
| Application: | GSPT1 targeting Molecular Glue/PROTAC identification/optimization, CRBN targeting molecule design |
| Species reactivity: | human |
2,569.00€
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NEW
Molecular Glue/PROTAC Optimization Kit for GSPT2
Item number: BPS-83903
The Molecular Glue/PROTAC(R) Optimization Kit for GSPT2 is an AlphaLISA(R) assay designed for the testing and profiling of Molecular Glues (MG) and PROTACs (proteolysis targeting chimeras) targeting GSPT2 (G1 to S phase transition 2). The kit comes with enough recombinant GSPT2, biotinylated Cereblon-DDB1 complex,...
| Keywords: | GSPT2, Eukaryotic peptide chain release factor GTP-binding subunit ERF3B, G1 to S phase transition protein 2 homolog |
| Application: | GSPT2 targeting Molecular Glue/PROTAC identification/optimization, CRBN targeting molecule design |
| Species reactivity: | human |
2,569.00€
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Anti-Recombinant eRF3/GSPT1, clone A210
Item number: E-AN301511L.100
Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs...
| Keywords: | Anti-GSPT1, Anti-G1 to S phase transition protein 1 homolog, Anti-Eukaryotic peptide chain release factor GTP-binding... |
| Application: | WB |
| Host: | Rabbit |
| Species reactivity: | human, rat, mouse, monkey |
From 304.00€
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MRT2359
Item number: Cay44120-10
MRT2359 is a molecular glue degrader of G1 to S phase transition protein 1 homolog (GSPT1). It promotes the interaction between the E3 ubiquitin ligase cereblon and GSPT1, inducing the degradation of GSPT1 and termination of protein synthesis. InChI:...
| Keywords: | N-[2-fluoro-5-(trifluoromethoxy)phenyl]-carbamic acid, [2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindol-5-yl]... |
| Application: | Molecular glue GSPT1 (ERF3A) degrader |
| CAS | 2803881-11-8 |
| MW: | 495.39 D |
From 170.00€
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Anti-GSPT2
Item number: E-AB-19078.120
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability. Protein function: Involved in...
| Keywords: | Anti-eRF3b, Anti-ERF3B, Anti-GSPT2, Anti-G1 to S phase transition protein 2 homolog, Anti-Eukaryotic peptide chain release... |
| Application: | WB, IHC, ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 89.00€
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SJ6986
Item number: Cay34523-1
SJ6986 is a degrader of G1 to S phase transition 1 (GSPT1) and GSPT2. It reduces the levels of GSPT1 and GSPT2 in MV4-11 cells in a concentration-dependent manner. SJ6986 inhibits proliferation of MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cells (EC50s = 1.5, 0.4, 726, 336, and 3,583 nM, respectively) and reduces...
| Keywords: | N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide |
| Application: | GSPT1 / GSPT2 degrader |
| CAS | 2765625-93-0 |
| MW: | 497.4 D |
From 93.00€
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Anti-GSPT2
Item number: ATA-HPA044769.100
Protein function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the...
| Keywords: | Anti-eRF3b, Anti-ERF3B, Anti-GSPT2, Anti-G1 to S phase transition protein 2 homolog, Anti-Eukaryotic peptide chain release... |
| Application: | ICC, IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human |
From 246.00€
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Anti-GSPT1
Item number: ATA-HPA052488.100
Protein function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-...
| Keywords: | Anti-GSPT1, Anti-ERF3A, Anti-eRF3a, Anti-G1 to S phase transition protein 1 homolog, Anti-Eukaryotic peptide chain release... |
| Application: | WB, IHC, ICC |
| Host: | Rabbit |
| Species reactivity: | human |
From 330.00€
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Eukaryotic peptide chain release factor GTP-binding...
Item number: CSB-BP009966HU.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 1-499aa. Protein Length: Full Length. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged. Target Protein Sequence: MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE...
| Keywords: | eRF3a, GSPT1, ERF3A, G1 to S phase transition protein 1 homolog, Eukaryotic peptide chain release factor subunit 3a,... |
| Application: | Activity not tested |
| Expressed in: | Insect cells |
| Origin: | human |
| MW: | 99.8 kD |
From 489.00€
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Eukaryotic peptide chain release factor GTP-binding...
Item number: CSB-YP009966HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-499aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE...
| Keywords: | eRF3a, GSPT1, ERF3A, G1 to S phase transition protein 1 homolog, Eukaryotic peptide chain release factor subunit 3a,... |
| Application: | Activity not tested |
| Expressed in: | Yeast |
| Origin: | human |
| MW: | 59.8 kD |
From 347.00€
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Anti-GSPT1
Item number: CSB-PA009039.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-eRF3a, Anti-ERF3A, Anti-GSPT1, Anti-G1 to S phase transition protein 1 homolog, Anti-Eukaryotic peptide chain release... |
| Application: | ELISA, WB, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 126.00€
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SJ6986
Item number: TGM-T41257-100mg
Description: SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1]. Target: Others. Smiles: O=C1N(C(=O)C=2C1=CC(NS(=O)(=O)C3=C(OC(F)(F)F)C=CC=C3)=CC2)C4C(=O)NC(=O)CC4. References: Nishiguchi G, et al. Identification of Potent, Selective,...
| Application: | GSPT1 / GSPT2 degrader |
| CAS | 2765625-93-0 |
| MW: | 497.4 D |
From 46.00€
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