42 products were found matching "K03267"!

Recombinant human GSPT2 (G1 to S phase transition 2), encompassing amino acids 2-628(end). This construct contains an N-terminal GST-tag followed by a Thrombin cleavage site. The recombinant protein was affinity purified. GSPT2 (G1 to S phase transition 2), also known as eRF3b, is an essential...

Description: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD)...

The Molecular Glue/PROTAC(R) Optimization Kit for GSPT1 is an AlphaLISA(R) assay designed for the testing and profiling of Molecular Glues (MG) and PROTACs (proteolysis targeting chimera) targeting GSPT1 (G1 to S phase transition 1). The kit comes with enough recombinant GSPT1, biotinylated Cereblon-DDB1 complex,...

The Molecular Glue/PROTAC(R) Optimization Kit for GSPT2 is an AlphaLISA(R) assay designed for the testing and profiling of Molecular Glues (MG) and PROTACs (proteolysis targeting chimeras) targeting GSPT2 (G1 to S phase transition 2). The kit comes with enough recombinant GSPT2, biotinylated Cereblon-DDB1 complex,...

Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs...

MRT2359 is a molecular glue degrader of G1 to S phase transition protein 1 homolog (GSPT1). It promotes the interaction between the E3 ubiquitin ligase cereblon and GSPT1, inducing the degradation of GSPT1 and termination of protein synthesis. InChI:...

This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability. Protein function: Involved in...

SJ6986 is a degrader of G1 to S phase transition 1 (GSPT1) and GSPT2. It reduces the levels of GSPT1 and GSPT2 in MV4-11 cells in a concentration-dependent manner. SJ6986 inhibits proliferation of MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cells (EC50s = 1.5, 0.4, 726, 336, and 3,583 nM, respectively) and reduces...

Protein function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the...

Protein function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-...

Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 1-499aa. Protein Length: Full Length. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged. Target Protein Sequence: MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE...

Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-499aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE...