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SJ6986
Item number: Cay34523-1
SJ6986 is a degrader of G1 to S phase transition 1 (GSPT1) and GSPT2. It reduces the levels of GSPT1 and GSPT2 in MV4-11 cells in a concentration-dependent manner. SJ6986 inhibits proliferation of MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cells (EC50s = 1.5, 0.4, 726, 336, and 3,583 nM, respectively) and reduces...
| Keywords: | N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide |
| Application: | GSPT1 / GSPT2 degrader |
| CAS | 2765625-93-0 |
| MW: | 497.4 D |
From 93.00€
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SJ6986
Item number: TGM-T41257-100mg
Description: SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1]. Target: Others. Smiles: O=C1N(C(=O)C=2C1=CC(NS(=O)(=O)C3=C(OC(F)(F)F)C=CC=C3)=CC2)C4C(=O)NC(=O)CC4. References: Nishiguchi G, et al. Identification of Potent, Selective,...
| Application: | GSPT1 / GSPT2 degrader |
| CAS | 2765625-93-0 |
| MW: | 497.4 D |
From 46.00€
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