Simvastatin

Simvastatin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010344-5 5 mg -

6 - 10 business days*

32.00€
Cay10010344-25 25 mg -

6 - 10 business days*

57.00€
Cay10010344-50 50 mg -

6 - 10 business days*

85.00€
Cay10010344-100 100 mg -

6 - 10 business days*

135.00€
 
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the... more
Product information "Simvastatin"
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule. After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%. Simvastatin also suppresses TNF-induced NF-kappaB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer. Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia. Formal Name: 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid. CAS Number: 79902-63-9. Synonyms: MK-733. Molecular Formula: C25H38O5. Formula Weight: 418.6. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238 nm. SMILES: C[C@H]1C=CC2=C[C@H](C)C[C@H](OC(C(C)(C)CC)=O)C2[C@H]1CC[C@@H]3C[C@@H](O)CC(O3)=O. InChi Code: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23?/m0/s1. InChi Key: RYMZZMVNJRMUDD-OVOOIQHOSA-N.
Keywords: MK-733, 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10010344

Properties

Application: HMG-CoA reductase inhibitor
MW: 418.6 D
Formula: C25H38O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 79902-63-9| Find alternatives
KEGG ID : K00021 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H411
P Phrases: P264, P273, P280, P302+352, P321, P332+313, P362+364, P391, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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