A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.

Description: Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovascular disease. Target: Mitophagy, Autophagy, Apoptosis, Ferroptosis, HMG-CoA...

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...

Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051), potent competitive HMG-CoA reductase inhibitor, anti-hypercholesterolemic agent, cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids, inhibits the...