- Search results for K00021
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83 products were found matching "K00021"!
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Item number: ELK-ELK0431.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse HMGCR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse HMGCR. Next,...
Keywords: | Hmgcr, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Application: | ELISA |
Species reactivity: | mouse |
293.00€
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From 263.70€
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Item number: CDX-P0933-M050
Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks...
Keywords: | Eptastatin sodium salt, 3beta-Hydroxycompactin, Mevalothin |
Application: | HMG-CoA reductase inhibitor |
MW: | 446,51 D |
87.00€
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-10 %
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Item number: ELK-ELK6333.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat HMGCR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat HMGCR. Next,...
Keywords: | Hmgcr, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Application: | ELISA |
Species reactivity: | rat |
365.00€
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From 328.50€
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-10 %
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Item number: ELK-ELK5163.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HMGCR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HMGCR. Next,...
Keywords: | HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Application: | ELISA |
Species reactivity: | human |
365.00€
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From 328.50€
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Item number: LKT-R5974.25
Statin, HMG-CoA reductase inhibitor, potential NADPH oxidase and PKC inhibitor.
Keywords: | (S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2- (methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-... |
Application: | HMGCoA reductase inhibitor |
CAS | 147098-20-2 |
MW: | 1001,14 D |
From 223.00€
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Item number: Cay10010338-50
Lovastatin is a fungal metabolite that has been found in A. terreus and an inhibitor of HMG-CoA reductase (Ki = 1.4 nM). It is also a prodrug form of the HMG-CoA reductase inhibitor lovastatin hydroxy acid (Cay-10010339). Lovastatin (8 mg/kg per day) reduces plasma cholesterol levels in dogs. It suppresses...
Keywords: | 2S-methyl-butanoic acid,... |
Application: | NF-kappaB activation inhibitor |
CAS | 75330-75-5 |
MW: | 404.5 D |
From 35.00€
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Item number: NSJ-RQ7289
0.5mg/ml if reconstituted with 0.2ml sterile DI water. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in...
Keywords: | Anti-HMG-CoA reductase, Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG CoA Reductase Antibody / HMGCR |
Application: | WB, IHC (paraffin), FC, Direct ELISA |
Host: | Rabbit |
Species reactivity: | human |
755.00€
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Item number: Cay10010344-5
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | MK-733,... |
Application: | HMG-CoA reductase inhibitor |
CAS | 79902-63-9 |
MW: | 418.6 D |
From 43.00€
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Item number: Cay10493-50
Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively. Formulations containing atorvastatin have been used in the treatment of...
Keywords: | 2-(4-fluorophenyl)-betaR,deltaR-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic... |
Application: | HMGCR inhibitor |
CAS | 357164-38-6 |
MW: | 577.7 D |
From 43.00€
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Item number: Cay10010334-10
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid |
Application: | HMG-CoA reductase inhibitor |
CAS | 93957-54-1 |
MW: | 411.5 D |
From 54.00€
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Item number: Cay12029-10
Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the...
Keywords: | ZD 4522,... |
Application: | HMG-CoA reductase inhibitor |
CAS | 287714-41-4 |
MW: | 481.5 D |
From 76.00€
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Item number: Cay18115-10
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity by enhancing the degradation of HMG-CoA reductase in various animal models. SR-12813 is also a high affinity ligand for human and rabbit pregnane X receptors (Kd = 41 nM, EC50 = 137 nM for hPXR in vitro) and can induce cytochrome P450...
Keywords: | GW 485801, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid P,P,P',P'-tetraethyl ester |
Application: | HMG-CoA reductase degradation enhancer, Pregnane X receptor ligand |
CAS | 126411-39-0 |
MW: | 504.5 D |
From 115.00€
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