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Rosuvastatin Calcium
Rosuvastatin Calcium

Item number: LKT-R5974.25

Statin, HMG-CoA reductase inhibitor, potential NADPH oxidase and PKC inhibitor.
Keywords: (S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2- (methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-...
Application: HMGCoA reductase inhibitor
CAS 147098-20-2
MW: 1001,14 D
From 169.00€ *
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Lovastatin
Lovastatin

Item number: Cay10010338-50

Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Cay-10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form,...
Keywords: 2S-methyl-butanoic acid,...
Application: NF-kappaB activation inhibitor
CAS 75330-75-5
MW: 404.5 D
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Atorvastatin (calcium salt)
Atorvastatin (calcium salt)

Item number: Cay10493-50

Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively. Formulations containing atorvastatin have been used in the treatment of...
Keywords: Cardyl, Lipitor(R),...
Application: HMGCR inhibitor
CAS 134523-03-8
MW: 578.7 D
From 32.00€ *
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Simvastatin
Simvastatin

Item number: Cay10010344-25

Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule. After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%. Simvastatin also suppresses TNF-induced NF-kappaB...
Keywords: MK-733,...
Application: HMG-CoA reductase inhibitor
CAS 79902-63-9
MW: 418.6 D
From 32.00€ *
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Fluvastatin
Fluvastatin

Item number: Cay10010334-10

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme) that binds to the HMG-CoA binding site. It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin (2 mg/kg per day) inhibits increases in serum cholesterol, triglycerides, phospholipids, and...
Keywords: Leschol(R), 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
Application: HMG-CoA reductase inhibitor
CAS 93957-54-1
MW: 411.5 D
From 40.00€ *
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Simvastatin
Simvastatin

Item number: LKT-S3449.500

A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Application: HMG-CoA reductase inhibitor
CAS 79902-63-9
MW: 418,57 D
From 65.00€ *
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Rosuvastatin
Rosuvastatin

Item number: Cay12029-10

Rosuvastatin is a potent HMG-CoA reductase inhibitor (IC50 = 5 nM). It is a fully-synthetic inhibitor that is designed to maximize the points of contact with, and inhibition of, HMG-CoA reductase. Formulations containing rosuvastatin reduce low-density lipoprotein (LDL) and C-reactive protein and increase...
Keywords: ZD 4522,...
Application: HMG-CoA reductase inhibitor
CAS 287714-41-4
MW: 481.5 D
From 55.00€ *
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Lovastatin
Lovastatin

Item number: AG-CN2-0051-M025

Statin compound, potent competitive HMG-CoA reductase inhibitor, anti-hypercholesterolemic agent, Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids, inhibits the isoprenylation of Ras and Rho family GTPases, causes...
Keywords: Mevilonin, MK-803, 6-alpha-Methylcompactin, BRN 3631990
Application: NF-kappaB activation inhibitor
CAS 75330-75-5
MW: 404,6 D
From 22.00€ *
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Clinofibrate
Clinofibrate

Item number: Cay31109-10

Clinofibrate is a hypolipidemic agent. It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3alpha-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner. Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and...
Keywords: S-8527, 2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-butanoic acid
Application: Hypolipidemic agent, HMG-CoA reductase inhibitor
CAS 30299-08-2
MW: 468.6 D
From 112.00€ *
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Fluvastatin sodium
Fluvastatin sodium

Item number: LKT-F4482.10

An anticholesterol agent. It is a HMG-CoA reductase inhibitor and antioxidant.
Keywords: Fluindostatin, XU-62-320
Application: HMG-CoA reductase inhibitor
CAS 93957-55-2
MW: 433,45 D
From 51.00€ *
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Pravastatin
Pravastatin

Item number: Cay10010342-10

Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Cay-10010340). In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per...
Keywords: (betaR,deltaR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-nap...
Application: HMG-CoA reductase inhibitor
CAS 81093-37-0
MW: 424.5 D
From 37.00€ *
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2-hydroxy Atorvastatin (calcium salt)
2-hydroxy Atorvastatin (calcium salt)

Item number: Cay30974-1

2-hydroxy Atorvastatin is an active metabolite of the HMG-CoA reductase inhibitor atorvastatin (Cay-10493). 2-hydroxy Atorvastatin is formed from atorvastatin by the cytochrome P450 (CYP) isoform CYP3A4. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances...
Keywords: o-hydroxy Atorvastatin, ortho-hydroxy Atorvastatin, BMS 243887-01, PD 152873,...
Application: Active metabolite (HMG-CoA reductase inhibitor)
CAS 265989-46-6
MW: 593.7 D
249.00€ *
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