SB-649868

SB-649868 is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 0.31 and 0.39 nM, respectively). In vivo, SB-649868 (3 and 10 mg/kg) decreases wakefulness and latency to fall asleep in rats. It also reduces binge eating of highly palatable food in a female rat model of stress-induced binge eating.Formal Name: N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide. CAS Number: 380899-24-1. Synonyms: GSK 649868. Molecular Formula: C26H24FN3O3S. Formula Weight: 477.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15mg/mL, DMF:PBS (pH 7.2) (1:20): 0.04mg/mL, DMSO: 10mg/mL, Ethanol: 0.3mg/mL. lambdamax: 210, 268 nm. SMILES: O=C(C1=C(C2=CC=C(F)C=C2)SC(C)=N1)N3CCCC[C@H]3CNC(C4=C(C=CO5)C5=CC=C4)=O. InChi Code: InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-8-10-18(27)11-9-17)26(32)30-13-3-2-5-19(30)15-28-25(31)21-6-4-7-22-20(21)12-14-33-22/h4,6-12,14,19H,2-3,5,13,15H2,1H3,(H,28,31)/t19-/m0/s1. InChi Key: ZJXIUGNEAIHSBI-IBGZPJMESA-N.