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Item number: Cay29477-1

SB-649868 is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 0.31 and 0.39 nM, respectively). In vivo, SB-649868 (3 and 10 mg/kg) decreases wakefulness and latency to fall asleep in rats. It also reduces binge eating of highly palatable food in a female rat model of stress-induced binge eating.Formal...

Keywords:	GSK 649868, N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide
Application:	Orexin receptor (Ox-1-R, Ox-2-R) antagonist
CAS	380899-24-1
MW:	477.6 D

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