SB-273005
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A nonpeptide alphaVbeta3 and alphaVbeta5 integrin antagonist (Kis =1.2 and 0.3 nM, respectively),... more
Product information "SB-273005"
A nonpeptide alphaVbeta3 and alphaVbeta5 integrin antagonist (Kis =1.2 and 0.3 nM, respectively), reduces paw edema and increases bone density in a rat model of adjuvant-induced arthritis at 30 and 60 mg/kg, reduces the number of Th2 cells and production of IL-10 in pregnant mice at 3 mg/kg. Formulation: A solid. InChI: InChI=1S/C22H24F3N3O4/c1-26-19-4-2-3-17(27-19)7-8-32-18-6-5-14-9-15(11-20(29)30)21(31)28(12-16(14)10-18)13-22(23,24)25/h2-6,10,15H,7-9,11-13H2,1H3,(H,26,27)(H,29,30)/t15-/m0/s1. InChIKey: KSSPHFGIOASRDE-HNNXBMFYSA-N. SMILES: OC(C[C@@H]1CC2=CC=C(OCCC3=CC=CC(NC)=N3)C=C2CN(C1=O)CC(F)(F)F)=O
| Keywords: | 2,3,4S,5-tetrahydro-8-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-1H-2-benzazepine-4-acetic acid |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 34404 |
Properties
| Application: | Nonpeptide alphaVbeta3 / alphaVbeta5 integrin antagonist |
| MW: | 451.44 D |
| Formula: | C22H24F3N3O4 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 205678-31-5| Matching products |
| KEGG ID : | K06487 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P301+310, P330, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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