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SB-273005
Item number: Cay34404-5
A nonpeptide alphaVbeta3 and alphaVbeta5 integrin antagonist (Kis =1.2 and 0.3 nM, respectively), reduces paw edema and increases bone density in a rat model of adjuvant-induced arthritis at 30 and 60 mg/kg, reduces the number of Th2 cells and production of IL-10 in pregnant mice at 3 mg/kg. Formulation: A solid....
| Keywords: | 2,3,4S,5-tetrahydro-8-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-1H-2-benzazepine-4-acetic acid |
| Application: | Nonpeptide alphaVbeta3 / alphaVbeta5 integrin antagonist |
| CAS | 205678-31-5 |
| MW: | 451.44 D |
From 97.00€
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SB273005
Item number: TGM-T6657-1mg
Description: SB273005 is an orally active and potent nonpeptide integrin alphavbeta3 antagonist that inhibits alphavbeta3 and alphavbeta5 and reduces the production of Th2 cells and the cytokine IL-10 in pregnant mice. Target: Integrin. Smiles: C(C(O)=O)[C@@H]1CC=2C(CN(CC(F)(F)F)C1=O)=CC(OCCC=3N=C(NC)C=CC3)=CC2....
| CAS | 205678-31-5 |
| MW: | 451.44 D |
64.00€
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