SB-216763

SB-216763
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010246-5 5 mg -

6 - 10 business days*

74.00€
Cay10010246-10 10 mg -

6 - 10 business days*

140.00€
Cay10010246-50 50 mg -

6 - 10 business days*

590.00€
Cay10010246-100 100 mg -

6 - 10 business days*

1,033.00€
 
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an... more
Product information "SB-216763"
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3alpha with an IC50 value of 34 nM (similar potency for GSK3beta). It stimulates glycogen synthesis in Chang human liver cells with an EC50 value of 3.6 µM and induces expression of a beta-catenin-LEF/Tcf regulated reporter gene in HEK293 cells. SB-216763 protects primary neurons from death induced by the PI3-kinase pathway. Formal Name: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS Number: 280744-09-4. Molecular Formula: C19H12Cl2N2O2. Formula Weight: 371.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 220, 428 nm. SMILES: Clc1ccc(c(Cl)c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12. InChi Code: InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25). InChi Key: JCSGFHVFHSKIJH-UHFFFAOYSA-N.
Keywords: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Supplier: Cayman Chemical
Supplier-Nr: 10010246

Properties

Application: GSK inhibitor
MW: 371.2 D
Formula: C19H12Cl2N2O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 280744-09-4| Find alternatives
KEGG ID : K03083 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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