SB-200646 (hydrochloride)

SB-200646 is a dual antagonist of the serotonin (5-HT) receptor subtypes 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B (pA2 = 7.5 in rat stomach fundus preparations). It is selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, alpha1-, alpha2A-, alpha2B-, beta1-, and beta2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all). SB-200646 (20 and 40 mg/kg) reverses mCPP-induced hypophagia and decreases in social interaction time, indicating anxiolytic-like behavior, in rats.Formal Name: N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-urea, monohydrochloride. CAS Number: 143797-62-0. Molecular Formula: C15H14N4O . HCl. Formula Weight: 302.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: O=C(NC1=CC(C=CN2C)=C2C=C1)NC3=CC=CN=C3.Cl. InChi Code: InChI=1S/C15H14N4O.ClH/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13,/h2-10H,1H3,(H2,17,18,20),1H. InChi Key: IGRYPUQJEDJLHC-UHFFFAOYSA-N.