268 products were found matching "K04157"!

(+)-Fenfluramine is an agonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C. It induces serotonin release from superfused midbrain synaptosome preparations isolated from wild-type mice, but not 5-HT2B-/- mice, when used at concentrations of 0. or 1 µM. (+)-Fenfluramine (3 or 10 mg/kg) reduces food...

Metabolite of clozapine. It is 5-HT2 serotonin receptor antagonist.

Serotonin-d4 is intended for use as an internal standard for the quantification of serotonin (Cay-14332) by GC- or LC-MS. Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the...

Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract. Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low...

A mixture of SR 46349 and SR 46615

An analytical reference standard categorized as an anorectic, decreases oxycodone intake and has positive effects on self-administration and relapse vulnerability in rats, regulated as a Schedule IV compound in the United States, intended for research and forensic applications

Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM). It is also an antagonist of histamine H1, alpha1a-, alpha2b-, and alpha2C-adrenergic, and M3...

A 5-HT2 antagonist (IC50 = 0.12 nM for the rat receptor), selective for 5-HT2 over 5-HT1A, 5-HT3, alpha1-AR, dopamine D2 (IC50s = 75, 6,600, 4.3, and 390 nM for the rat receptors), and histamine H1 receptors (IC50 = 50 nM for the guinea pig receptor), an antagonist of the dopamine D4 receptor (Ki = 2.93 nM for the...

A 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist, induces calcium accumulation in CHO-K1 cells expressing 5-HT2A, 5-HT2B, or 5-HT2C receptors (EC50s = 309.03, 177.83, and 338.84 nM, respectively, for the human receptors), binds to the 5-HT3 receptor (Ki = 2.1 nM), decreases food intake in rats at 2.5, 5, or 10 mg/kg,...

Ritanserin is a selective antagonist of the serotonin (5-HT) receptor subtype, 5-HT2A. In a radioligand binding assay, ritanserin exhibits high selectivity for 5-HT2A over 5-HT1 receptors (IC50s = 0.9 nM and >1000 nM, respectively). It also demonstrates relatively low affinity for histamine H1, dopamine D2,...

Paliperidone is an atypical antipsychotic. It is an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively), as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively). Paliperidone also binds to alpha1- and alpha2-adrenergic receptors, histamine H1 receptors, and...

Clozapine is a partial agonist at the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 180 nM). It also binds to the 5-HT2A, 5-HT2C, 5-HT3, 5-HT6 and 5-HT7 receptors (Kis = 3.3, 13, 110, 4, and 21 nM, respectively), as well as the histamine H1 and alpha1-adrenergic receptors (Kis = 2.1 and 23 nM, respectively). It...