SAR-020106

SAR-020106
Item number Size Datasheet Manual SDS Delivery time Quantity Price
SYN-1189-M001 1 mg -

3 - 9 business days*

250.00€
SYN-1189-M005 5 mg -

3 - 9 business days*

507.00€
SYN-1189-M010 10 mg -

3 - 9 business days*

796.00€
SYN-1189-M050 50 mg -

3 - 9 business days*

-
SYN-1189-M100 100 mg -

3 - 9 business days*

-
 
Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an... more
Product information "SAR-020106"
Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.
Keywords: SAR020106
Supplier: SYNkinase
Supplier-Nr: 1189

Properties

Application: Chk1 inhibitor
MW: 382,9 D
Formula: C19H19ClN6O
Purity: >95%
Format: Solid

Database Information

CAS : 1184843-57-9| Matching products
KEGG ID : K02216 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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