165 products were found matching "K02216"!

An inhibitor of Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively), selective for Chk1 and WEE1 over PKC (IC50 = 3.4 µM) and Cdk4 (IC50 = 3.75 µM), selective for Chk1 and WEE1 over c-Src and the PDGF and FGF receptors (IC50s = >50 µM for all), and other CDKs (IC50s = >50 µM), sensitizes SKOV3 and OVCAR-3 ovarian...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-Chk1 (Ser280) antibody detects checkpoint kinase 1 when phosphorylated at serine 280. Chk1 is a serine threonine kinase encoded by the CHEK1 gene and functions as a key regulator of the DNA...

Checkpoint kinase 1 (Chk1) is a serine/threonine kinase and downstream effector of ataxia-telangiectasia and RAD3-related protein/kinase (ATR) in the cellular DNA damage response. It is composed of an N-terminal kinase domain, a flexible linker region, a serine/glutamine cluster, and a C-terminal regulatory domain,...

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses,...

Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to...

[pS345]-Chk1 (340-349) is a peptide fragment of the serine/threonine kinase checkpoint kinase 1 (Chk1) that is phosphorylated at the serine in position 345 (Ser345). Phosphorylation at Ser345 and Ser317 is involved in activation of Chk1, which results in cell cycle arrest at the S or G2/M phase. InChI:...

Rabbit Polyclonal CHEK1 Antibody against Human checkpoint kinase 1. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000032113: 92%, ENSRNOG00000071217:...

Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...

Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...

Protein function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by...

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 µM). In...

LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents. It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation. LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of...