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SAR-020106
Item number: SYN-1189-M001
Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to...
| Keywords: | SAR020106 |
| Application: | Chk1 inhibitor |
| CAS | 1184843-57-9 |
| MW: | 382,9 D |
From 293.00€
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SAR-020106
Item number: TGM-T21331-100mg
Description: SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme. Target: Chk. Smiles: C[C@H](CN(C)C)Oc1nc(Nc2cc3cccc(Cl)c3cn2)cnc1C#N. References: Walton M I , Eve P D , Hayes A , et al. The Preclinical Pharmacology and Therapeutic Activity...
| CAS | 1184843-57-9 |
| MW: | 382.85 D |
From 45.00€
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