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RU.521

TargetMol
RU.521
Item number Size Datasheet Manual SDS Delivery time Quantity Price
TGM-T5486-1mg 1 mg

7 - 10 business days*

39.00€
TGM-T5486-2mg 2 mg

7 - 10 business days*

55.00€
TGM-T5486-1mL 1 ml

7 - 10 business days*

91.00€
TGM-T5486-5mg 5 mg

7 - 10 business days*

91.00€
TGM-T5486-10mg 10 mg

7 - 10 business days*

146.00€
TGM-T5486-25mg 25 mg

7 - 10 business days*

264.00€
TGM-T5486-50mg 50 mg

7 - 10 business days*

374.00€
TGM-T5486-100mg 100 mg

7 - 10 business days*

557.00€
TGM-T5486-200mg 200 mg - - -

7 - 10 business days*

794.00€
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
 
Description Product Citations Certificate of Analysis Reviews 0
Description
Description: RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse:... more
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Product information "RU.521"
Description: RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 µM), (human: IC50=2.94 µM). RU.521 is an inhibitor of the receptor activated by dsDNA (IC50=700 nM). RU.521 inhibits cGAS-mediated interferon upregulation. RU.521 reduces constitutive interferon expression in macrophages derived from a mouse model of Aicardi-Goutieres syndrome. Target: DNA, cGAS. Smiles: Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1. References: Tan J, et al. Synthesis and Pharmacological Evaluation of Tetrahydro-gamma-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J Med Chem. 2021 Jun 10,64(11):7667-7690.
Keywords: RU320521
Supplier: TargetMol
Supplier-Nr: T5486

Properties

Application: cGAS inhibitor
MW: 415.23 D
Formula: C19H12Cl2N4O3

Database Information

CAS : 2262452-06-0| Matching products
KEGG ID : K17834 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Product Citations
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