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Item number: Cay31765-5

RU-521 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.11 µM). It inhibits dsDNA-, but not IFN-beta- or 5'ppp-HP20 RNA-, induced IFN-beta1-dependent gene expression in reporter assays and does not inhibit Pam3CSK4-, poly(I:C)-, or LPS-induced Il6 mRNA expression in RAW 264.7 cells, indicating...

Keywords:	RU-320521, 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone
Application:	cGAS inhibitor
CAS	2262452-06-0
MW:	415.2 D

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RU.521

Item number: TGM-T5486-1mg

Description: RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 µM), (human: IC50=2.94 µM). RU.521 is an inhibitor of the receptor activated by dsDNA (IC50=700 nM). RU.521 inhibits cGAS-mediated interferon upregulation. RU.521 reduces constitutive interferon expression in...

Keywords:	RU320521
Application:	cGAS inhibitor
CAS	2262452-06-0
MW:	415.23 D

From 39.00€ *

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