Ro 0335

Ro 0335 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and an active metabolite of the antiviral prodrug elsulfavirine. It inhibits HIV-1 reverse transcriptase in a cell-free assay and the replication of HIV-1 in MT-4 cells (IC50s = 8.1 and 1.1 nM, respectively). Ro 0335 also selectively inhibits human carbonic anhydrase VII (CAVII, Ki = 9.7 nM) over human CAI and CAIII-VI (Kis = >125 nM for all) but also inhibits human CAII, CAIX, CAXII, CAXIII, and CAXIV (Kis = 35.5, 72.1, 62.3, 52.2, and 15.4 nM, respectively).Formal Name: N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-benzeneacetamide. CAS Number: 867365-76-2. Synonyms: VM 1500A. Molecular Formula: C21H13BrCl2FN3O4S. Formula Weight: 573.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: N#CC1=CC(Cl)=CC(OC2=C(F)C(CC(NC3=C(Cl)C=C(S(=O)(N)=O)C=C3)=O)=CC=C2Br)=C1. InChi Code: InChI=1S/C21H13BrCl2FN3O4S/c22-16-3-1-12(20(25)21(16)32-14-6-11(10-26)5-13(23)8-14)7-19(29)28-18-4-2-15(9-17(18)24)33(27,30)31/h1-6,8-9H,7H2,(H,28,29)(H2,27,30,31). InChi Key: SBUUICLVCQQMFP-UHFFFAOYSA-N.