39 products were found matching "K24802"!

A non-nucleoside reverse transcriptase inhibitor, inhibits HIV-1 wild-type RT (IC50 = 0.017 µM) and RTL100I, RTE138R, RTY181C, RTY188H (IC50s = 0.43, 0.22, 2.5, and 0.2 µM, respectively), delays p27 antigenemia and the appearance of anti-SIV antibodies in rhesus monkeys infected with transgenic SIV expressing HIV-1...

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1nM for L100I, K103N, V106A, G190A and G190S mutants in vitro. Rilpivirine also reduces growth of...

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs (Ki= 2.93nM and 3.85-56.5nM, respectively). It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s =...

2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2',3'-dideoxyadenosine (ddA, Cay-36662) and didanosine (ddI, Cay-23715). It is formed from ddI via a 2',3'-dideoxyAMP intermediate by...

2',3'-Dideoxycytidine-5'-O-triphosphate is an active metabolite of the reverse transcriptase inhibitor zalcitabine (Cay-16019). It is an inhibitor of DNA polymerases beta and gamma (Kis = 1.32 and 0.034 µM, respectively, for the human enzymes). 2',3'-Dideoxycytidine-5'-O-triphosphate (1 mM) inhibits HIV-1...

2',3'-Dideoxyguanosine-5'-O-triphosphate (ddGTP) is a reverse transcriptase inhibitor (Kis = 13 and 6.7 nM for the visna virus and HIV-1 enzymes, respectively). ddGTP has been used in the synthesis of oligonucleotides containing a terminal ddG that are resistant to cleavage by severe acute respiratory syndrome...

2',3'-Dideoxythymidine-5'-O-triphosphate (ddTTP) is a reverse transcriptase inhibitor (Kis = 40 and 25 nM for the visna virus and HIV-1 enzymes, respectively). It also inhibits DNA polymerase gamma (Ki = 400 nM for the bovine enzyme). ddTTP has been used to terminate chain extension produced by the Taq polymerase in...

Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3'-azido-3'-deoxythymidine (zidovudine, Cay-15492) or 2',3'-dideoxyinosine (didanosine, Cay-23715),...

Azvudine is a nucleoside reverse transcriptase inhibitor (NRTI). It reduces viral infectivity in HIV-1-infected HEK293T cells (EC50 = 0.063 nM) and reduces viral replication in 2209-23 cells stably transfected with hepatitis C virus (HCV) genotype 1b (EC50 = 24 nM). In vivo, azvudine (0.7 mg/kg) reduces viral load...

Description: Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV. Target: Apoptosis, HIV Protease, NOD-like Receptor (NLR), Autophagy, Reverse Transcriptase, Nucleoside Antimetabolite/Analog. Smiles: CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O. References: Caron...

Description: Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. Target: Reverse Transcriptase, HIV Protease, Apoptosis. Smiles:...

Description: Loviride is a non-nucleoside reverse transcriptase inhibitor (IC50: 0.3 µM). Loviride inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. It is used for reverse transcriptase from HIV-1. Target: Others. Smiles: CC(=O)c1ccc(C)cc1NC(C(N)=O)c1c(Cl)cccc1Cl. References: Witvrouw M, et al. Activity of...