39 products were found matching "K24802"!

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1nM for L100I, K103N, V106A, G190A and G190S mutants in vitro. Rilpivirine also reduces growth of...

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs (Ki= 2.93nM and 3.85-56.5nM, respectively). It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s =...

2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2',3'-dideoxyadenosine (ddA, Cay-36662) and didanosine (ddI, Cay-23715). It is formed from ddI via a 2',3'-dideoxyAMP intermediate by...

2',3'-Dideoxycytidine-5'-O-triphosphate is an active metabolite of the reverse transcriptase inhibitor zalcitabine (Cay-16019). It is an inhibitor of DNA polymerases beta and gamma (Kis = 1.32 and 0.034 µM, respectively, for the human enzymes). 2',3'-Dideoxycytidine-5'-O-triphosphate (1 mM) inhibits HIV-1...

2',3'-Dideoxyguanosine-5'-O-triphosphate (ddGTP) is a reverse transcriptase inhibitor (Kis = 13 and 6.7 nM for the visna virus and HIV-1 enzymes, respectively). ddGTP has been used in the synthesis of oligonucleotides containing a terminal ddG that are resistant to cleavage by severe acute respiratory syndrome...

2',3'-Dideoxythymidine-5'-O-triphosphate (ddTTP) is a reverse transcriptase inhibitor (Kis = 40 and 25 nM for the visna virus and HIV-1 enzymes, respectively). It also inhibits DNA polymerase gamma (Ki = 400 nM for the bovine enzyme). ddTTP has been used to terminate chain extension produced by the Taq polymerase in...

Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3'-azido-3'-deoxythymidine (zidovudine, Cay-15492) or 2',3'-dideoxyinosine (didanosine, Cay-23715),...

Azvudine is a nucleoside reverse transcriptase inhibitor (NRTI). It reduces viral infectivity in HIV-1-infected HEK293T cells (EC50 = 0.063 nM) and reduces viral replication in 2209-23 cells stably transfected with hepatitis C virus (HCV) genotype 1b (EC50 = 24 nM). In vivo, azvudine (0.7 mg/kg) reduces viral load...

Description: Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV. Target: Apoptosis, HIV Protease, NOD-like Receptor (NLR), Autophagy, Reverse Transcriptase, Nucleoside Antimetabolite/Analog. Smiles: CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O. References: Caron...

Description: Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. Target: Reverse Transcriptase, HIV Protease, Apoptosis. Smiles:...

Description: Loviride is a non-nucleoside reverse transcriptase inhibitor (IC50: 0.3 µM). Loviride inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. It is used for reverse transcriptase from HIV-1. Target: Others. Smiles: CC(=O)c1ccc(C)cc1NC(C(N)=O)c1c(Cl)cccc1Cl. References: Witvrouw M, et al. Activity of...

Description: Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Target: CRISPR/Cas9, HIV...