RCGD 423

RCGD 423 is a modulator of gp130. It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Cay-29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.Formal Name: N-(4-bromophenyl)-4-phenyl-2-thiazolamine. CAS Number: 108237-91-8. Molecular Formula: C15H11BrN2S. Formula Weight: 331.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. SMILES: BrC(C=C1)=CC=C1NC2=NC(C3=CC=CC=C3)=CS2. InChi Code: InChI=1S/C15H11BrN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H,(H,17,18). InChi Key: OUFYYVAASPLOAA-UHFFFAOYSA-N.