PTI-125 (hydrochloride)

PTI-125 is a purported binding agent of filamin A, a cytoskeletal protein said to stabilize the interaction between amyloid-beta (1-42) (Abeta42) and the alpha7 nicotinic acetylcholine receptor (nAChR). PTI-125 reportedly binds to filamin A to reverse an aberrant conformational change induced by Abeta42, which prevents and reverses Abeta42-alpha7 nAChR binding and improves neuropathological outcomes in the 3xTg mouse model of Alzheimer's disease. However, the data regarding PTI-125 have prompted expressions of concern by the journals in which the data were published.Formal Name: 8-methyl-1-(phenylmethyl)-1,4,8-triazaspiro[4.5]decan-2-one, dihydrochloride. CAS Number: 2480226-06-8. Molecular Formula: C15H21N3O . 2HCl. Formula Weight: 332.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: CN1CCC(NCC2=O)(N2CC3=CC=CC=C3)CC1.Cl.Cl. InChi Code: InChI=1S/C15H21N3O.2ClH/c1-17-9-7-15(8-10-17)16-11-14(19)18(15)12-13-5-3-2-4-6-13,,/h2-6,16H,7-12H2,1H3,2*1H. InChi Key: IZIPGYSLPYPJDQ-UHFFFAOYSA-N.