Propentofylline

Propentofylline is a xanthine derivative and neuroprotective agent. It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM. Propentofylline (20 µg/ml) reduces cell death induced by amyloid-beta (1-42) (Abeta42, Cay-20574) in primary rat hippocampal neurons. Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO. It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.Formal Name: 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione. CAS Number: 55242-55-2. Synonyms: HOE 285, HWA 285. Molecular Formula: C15H22N4O3. Formula Weight: 306.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: slightly soluble, Chloroform: slightly soluble. lambdamax: 274 nm. SMILES: CCCN(C=N1)C2=C1N(C)C(N(CCCCC(C)=O)C2=O)=O. InChi Code: InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3. InChi Key: RBQOQRRFDPXAGN-UHFFFAOYSA-N.