PRIMA-1

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.Formal Name: 2,2-bis(hydroxymethyl)-3-quinuclidinone. CAS Number: 5608-24-2. Molecular Formula: C9H15NO3. Formula Weight: 185.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 50 mg/ml. SMILES: OCC1(CO)N2CCC(CC2)C1=O. InChi Code: InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2. InChi Key: RFBVBRVVOPAAFS-UHFFFAOYSA-N.