PH-797804

PH-797804 is an inhibitor of p38alpha MAPK with an IC50 value of 26 nM in a cell-free assay. It is 4-fold more selective for p38alpha compared to p38beta and does not inhibit JNK2 or ERK at concentrations up to 1 µM. PH-797804 treatment for 10 days in vivo demonstrates anti-inflammatory activity in chronic inflammatory disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and collagen-induced arthritis in mice.Formal Name: 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethyl-benzamide. CAS Number: 586379-66-0. Molecular Formula: C22H19BrF2N2O3. Formula Weight: 477.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/mL, DMSO: 14 mg/mL, DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL, Ethanol: 2.5 mg/mL. lambdamax: 219, 309 nm. SMILES: FC1=CC(F)=C(COC2=C(Br)C(N(C3=C(C)C=CC(C(NC)=O)=C3)C(C)=C2)=O)C=C1. InChi Code: InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28). InChi Key: KCAJXIDMCNPGHZ-UHFFFAOYSA-N.