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Item number: Cay20244-1

PH-797804 is an inhibitor of p38alpha MAPK with an IC50 value of 26 nM in a cell-free assay. It is 4-fold more selective for p38alpha compared to p38beta and does not inhibit JNK2 or ERK at concentrations up to 1 µM. PH-797804 treatment for 10 days in vivo demonstrates anti-inflammatory activity in chronic...

Keywords:	3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethyl-benzamide
Application:	p38alpha MAPK inhibitor
CAS	586379-66-0
MW:	477.3 D

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PH-797804

Item number: TGM-T1974-100mg

Description: PH-797804 is a pyridinone inhibitor of p38alpha (IC50: 26 nM, in a cell-free assay), 4-fold more selective versus p38beta and does not inhibit JNK2. Target: p38 MAPK, Autophagy. Smiles: CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O. References: Hope HR, et al, J Pharmacol Exp Ther, 2009,...

Keywords:	PH797804
Application:	p38alpha MAPK inhibitor
CAS	586379-66-0
MW:	477.3 D

From 37.00€ *

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Review

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