PGPC-d6

PGPC-d6
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay25746-500 500 µg -

6 - 10 business days*

344.00€
Cay25746-1 1 mg -

6 - 10 business days*

649.00€
 
PGPC-d6 is intended for use as an internal standard for the quantification of PGPC (Cay-10044),... more
Product information "PGPC-d6"
PGPC-d6 is intended for use as an internal standard for the quantification of PGPC (Cay-10044), as well as related fragmented short-chain fatty acid remnants of phospholipid oxidation, by GC- or LC-MS. PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. It is found as a component in mildly oxidized LDL (MM-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC). PGPC activates peroxisome proliferator-activated receptor alpha (PPARalpha) in a concentration-dependent manner in a cell-based ligand-binding assay. It increases VCAM1 and E-selectin expression in human aortic endothelial cells (HAECs), as well as HAEC binding by monocytes and polymorphonuclear neutrophils (PMNs), in a concentration-dependent manner. PGPC (37.5 µM) also increases total 5-lipoxygenase metabolites in murine resident peritoneal macrophages (RPMs) and induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro when used at a concentration of 50 µM. PGPC levels are increased in serum, LDL, and peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease. UVA irradiation increases PGPC levels in cultured human skin fibroblasts.Formal Name: (R)-2-((4-carboxybutanoyl-2,2,3,3,4,4-d6)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate. Synonyms: 1-Palmitoyl-2-glutaryl Phosphatidylcholine-d6. Molecular Formula: C29H50D6NO10P. Formula Weight: 615.8. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: 1 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 292 nm. SMILES: O=P(OCC[N+](C)(C)C)([O-])OC[C@H](OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1/i18D2,19D2,21D2. InChi Key: CDZVJFRXJAUXPP-KXHOITNYSA-N. Side Chain Carbon Sum: 21:0.
Keywords: 1-Palmitoyl-2-glutaryl Phosphatidylcholine-d6, (R)-2-((4-carboxybutanoyl-2,2,3,3,4,4-d6)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
Supplier: Cayman Chemical
Supplier-Nr: 25746

Properties

Application: Oxidized phospholipid, GC-MS, LC-MS, internal standard
MW: 615.8 D
Formula: C29H50D6NO10P
Purity: >99% deuterated forms (d1-d6)
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H333
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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