PF-06726304
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Larger quantity required? Request bulk
PF-06726304 is an inhibitor of enhancer of zeste homolog 2 (EZH2, Ki = 0. nM). In vivo,... more
Product information "PF-06726304"
PF-06726304 is an inhibitor of enhancer of zeste homolog 2 (EZH2, Ki = 0. nM). In vivo, PF-06726304 (200 and 300 mg/kg) reduces tumor volume and intratumor histone methylation in a Karpas-422 mouse xenograft model. InChI: InChI=1S/C22H21Cl2N3O3/c1-10-7-11(2)25-21(28)16(10)9-27-6-5-14-17(23)8-15(20(24)19(14)22(27)29)18-12(3)26-30-13(18)4/h7-8H,5-6,9H2,1-4H3,(H,25,28), InChIKey: PDKDOPJQPKXNCT-UHFFFAOYSA-N, SMILES: O=C(C1=C(C(C2=C(ON=C2C)C)=CC(Cl)=C1CC3)Cl)N3CC4=C(C=C(NC4=O)C)C
| Keywords: | 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 44260 |
Properties
| Application: | EZH2 inhibitor |
| MW: | 446.33 D |
| Formula: | C22H21Cl2N3O3 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 1616287-82-1| Matching products |
| KEGG ID : | K11430 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319 |
| P Phrases: | P264, P270, P280, P301+310, P302+352, P305+351+338, P321, P330, P332+313, P337+313, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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