142 products were found matching "K11430"!
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Anti-mes-2
Item number: CSB-PA515708XA01CXY.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally...
| Keywords: | Anti-E(z) homolog, EC=2.1.1.356, Anti-Maternal-effect sterile protein 2, Anti-Histone-lysine N-methyltransferase mes-2,... |
| Application: | ELISA, WB |
| Species reactivity: | Caenorhabditis elegans |
From 147.00€
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Anti-EZH2
Item number: ABS-KC-3192.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
| Keywords: | Anti-Histone-lysine N-methyltransferase EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine... |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Anti-EZH2
Item number: ABS-OC-533.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
| Keywords: | Anti-Histone-lysine N-methyltransferase EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine... |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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CPI-1205
Item number: TGM-T8510-10mg
Description: CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 µM, EC50 : 0.032 µM) . Target: Histone Methyltransferase. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCN(CC(F)(F)F)CC4. References: Vaswani RG, et al. Identification of...
| Keywords: | Lirametostat |
| Application: | EZH2 inhibitor |
| CAS | 1621862-70-1 |
| MW: | 518.57 D |
From 84.00€
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EPZ005687
Item number: TGM-T1905-100mg
Description: EPZ005687, a potent and selective inhibitor of EZH2. Target: Histone Methyltransferase. Smiles: Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1. References: Knutson SK, et al. Nat Chem Biol, 2012, 8(11), 890-896.
| Application: | Lysine methyltranferase EZH2 inhibitor |
| CAS | 1396772-26-1 |
| MW: | 539.67 D |
From 54.00€
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GSK503
Item number: TGM-T1775-100mg
Description: GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. Target: Histone Methyltransferase. Smiles: CC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Béguelin W, et al. Cancer Cell. 2013, 23(5), 677-692
| Application: | EZH2 inhibitor |
| CAS | 1346572-63-1 |
| MW: | 526.67 D |
From 31.00€
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3-deazaneplanocin A HCl
Item number: TGM-T6360-100mg
Description: 3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor. Target: Others, Histone Methyltransferase. Smiles: Cl.Nc1nccc2n(cnc12)C1C=C(CO)C(O)C1O. References: Glazer RI, et al. Biochem Pharmacol, 1986, 35(24), 4523-4527.
| Application: | Apoptosis inducer, trimethylation inhibitor |
| CAS | 120964-45-6 |
| MW: | 298.73 D |
From 86.00€
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CPI-169 racemate
Item number: TGM-T6809-100mg
Description: CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: CCS(=O)(=O)N1CCC(CC1)C(C)n1c(C)c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c2ccccc12....
| Keywords: | CPI-169, CPI 169, CPI169 |
| Application: | EZH2 inhibitor |
| CAS | 1450655-76-1 |
| MW: | 528.66 D |
From 52.00€
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CPI-360
Item number: TGM-T6810-100mg
Description: CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 µM, EC50: 0.080 µM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. Target: Histone Methyltransferase, Apoptosis. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCOCC4. References: Vatolin S, et al....
| Keywords: | CPI360, Synonym 2, Synonym 2, CPI 360 |
| Application: | Selective EZH2 inhibitor |
| CAS | 1802175-06-9 |
| MW: | 437.53 D |
From 75.00€
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GSK343
Item number: TGM-T6059-100mg
Description: GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases. Target: Histone Methyltransferase, Autophagy. Smiles:...
| Application: | Cell-permeable EZH2 inhibitor |
| CAS | 1346704-33-3 |
| MW: | 541.69 D |
From 55.00€
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GSK126
Item number: Cay15415-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK126 is a selective, S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57...
| Keywords: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-... |
| Application: | Selective EZH2 methyltransferase inhibitor |
| CAS | 1346574-57-9 |
| MW: | 526.7 D |
From 85.00€
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PF-06821497
Item number: TGM-T12430-100mg
Description: PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition. Target: Histone Methyltransferase. Smiles: ClC1=C2C(=C(Cl)C=C1[C@H](OC)C3COC3)CCN(CC4=C(OC)C=C(C)NC4=O)C2=O. References: Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2)...
| Application: | Targets [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] (EZH2) |
| CAS | 1844849-10-0 |
| MW: | 467.34 D |
From 97.00€
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