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PF-06726304
Item number: Cay44260-1
PF-06726304 is an inhibitor of enhancer of zeste homolog 2 (EZH2, Ki = 0. nM). In vivo, PF-06726304 (200 and 300 mg/kg) reduces tumor volume and intratumor histone methylation in a Karpas-422 mouse xenograft model. InChI:...
| Keywords: | 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoqui... |
| Application: | EZH2 inhibitor |
| CAS | 1616287-82-1 |
| MW: | 446.33 D |
From 53.00€
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PF-06726304
Item number: TGM-T12428L-100mg
Description: PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively). Target: Histone Methyltransferase. Smiles: Cc1noc(C)c1-c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl....
| CAS | 1616287-82-1 |
| MW: | 446.33 D |
From 32.00€
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