PD 407824 (hydrate)

An inhibitor of Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively), selective for Chk1 and WEE1 over PKC (IC50 = 3.4 µM) and Cdk4 (IC50 = 3.75 µM), selective for Chk1 and WEE1 over c-Src and the PDGF and FGF receptors (IC50s = >50 µM for all), and other CDKs (IC50s = >50 µM), sensitizes SKOV3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin at 0.5 µM, induces myoblast differentiation into mature osteoblasts and hESC differentiation into cells with mesoderm or cytotrophoblast stem cell lineages when used in combination with BMP4. SMILES: O=C1NC(C2=C3C4=C(C=CC(O)=C4)NC3=CC(C5=CC=CC=C5)=C21)=O.O. InChi Code: InChI=1S/C20H12N2O3.H2O/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24,/h1-9,21,23H,(H,22,24,25),1H2. InChi Key: BYBJRPZQCMIOPE-UHFFFAOYSA-N