PD 0325901

PD 0325901
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13034-1 1 mg -

6 - 10 business days*

25.00€
Cay13034-5 5 mg -

6 - 10 business days*

63.00€
Cay13034-10 10 mg -

6 - 10 business days*

124.00€
Cay13034-25 25 mg -

6 - 10 business days*

248.00€
 
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK... more
Product information "PD 0325901"
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation with 1 µM PD 0325901 combined with 3 µM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages. Formal Name: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide. CAS Number: 391210-10-9. Molecular Formula: C16H14F3IN2O4. Formula Weight: 482.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238, 276, 313 nm. SMILES: FC1=C(F)C(NC2=CC=C(I)C=C2F)=C(C(NOC[C@H](O)CO)=O)C=C1. InChi Code: InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1. InChi Key: SUDAHWBOROXANE-SECBINFHSA-N.
Keywords: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 13034

Properties

Application: MEK inhibitor
MW: 482.2 D
Formula: C16H14F3IN2O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 391210-10-9| Find alternatives
KEGG ID : K04368 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H373, H400, H410
P Phrases: P260, P264, P270, P273, P301+310, P314, P321, P330, P391, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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