Pamoic Acid

Pamoic acid is a potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a beta-arrestin recruitment assay). It induces GPR35 translocation from the plasma membrane to the cytoplasm with an EC50 value of 22 nM. Pamoic acid also increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a. In vivo, pamoic acid has antinociceptive effects with an ED50 value of 40.5 mg/kg in a mouse abdominal constriction model of visceral pain perception. Pamoate salts, of which pamoic acid is the main constituent, have been used in drug formulations to extend the duration of action.Formal Name: 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid]. CAS Number: 130-85-8. Synonyms: Embonic Acid, NSC 30188, NSC 40132. Molecular Formula: C23H16O6. Formula Weight: 388.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.2 mg/ml, Methanol: slightly soluble. lambdamax: 237, 370 nm. SMILES: OC(C1=CC(C=CC=C2)=C2C(CC3=C(C=CC=C4)C4=CC(C(O)=O)=C3O)=C1O)=O. InChi Code: InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29). InChi Key: WLJNZVDCPSBLRP-UHFFFAOYSA-N.