26 products were found matching "K04276"!

Description: ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM). Target: Others. Smiles: C\C(\C=C1/SC(=S)N(CCCC(=O)Nc2ccc(C(O)=O)c(O)c2)C1=O)=C/c1ccccc1. References: Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US), 2010-2010...

Description: NPPB is a chloride channel blocker with IC50 of 80 nM . Target: Chloride channel. Smiles: OC(=O)c1cc(ccc1NCCCc1ccccc1)[N+]([O-])=O. References: Taniguchi Y , Tonai-Kachi H , Shinjo K . 5-Nitro-2-(3-Phenylpropylamino)benzoic Acid Is a GPR35 Agonist[J]. Pharmacology, 2008, 82(4):245-249.

Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-309aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI...

NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist. It has been shown to activate the GPR35-Galphai/o and GPR35-Galpha16 pathways in HEK293 cells, inducing intracellular calcium mobilization. NPPB has protonophoric activity and has been used to uncouple mitochondrial...

GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid). It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract. GPR35 is overexpressed in gastric cancer cells. CID-2745687 is a reversible,...

Lodoxamide is a potent agonist of GPR35 with an EC50 value of 1.61 nM in a beta-arrestin-2 interaction assay using CHO-K1 cells expressing the human receptor. It inhibits histamine release induced by compound 48/80 (Cay-22173), anti-IgE, or A23187 (Cay-11016) in isolated rat peritoneal mast cells (IC50s = 0.1-50 µM)...

Pamoic acid is a potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a beta-arrestin recruitment assay). It induces GPR35 translocation from the plasma membrane to the cytoplasm with an EC50 value of 22 nM. Pamoic acid also increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells...

Protein function: Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. [The UniProt Consortium]

Many G protein-coupled receptor 35 (GPR35) ligands have recently been identified including kynurenic acid (Cay-16762) and zaprinast (Cay-110010421). Multiple isoforms of this receptor have been reported and GPR35 mRNAs were detected in several tissues including intestine, lymphocytes, skeletal muscle, pancreatic...

YE 120 is an agonist of G protein-coupled receptor 35 (GPR35) with an EC50 value of 32 nM in a dynamic mass redistribution (DMR) assay using HT-29 cells. It induces beta-arrestin translocation in Tango GPR35-bla U2OS cells (EC50 = 10.2 µM). YE 120 (10 µM) promotes wound closure in YAMC colonic epithelial and IEC-6...

ML-145 is an antagonist of G protein-coupled receptor 35 (GPR35). It inhibits beta-arrestin recruitment induced by the GPR35 agonists zaprinast (Cay-10010421), cromolyn (Cay-21379), and pamoic acid (Cay-13946) in HEK293 cells expressing the human receptor (EC50s = 26, 22, and 8.3 nM, respectively). ML-145 inhibits...

3-Methoxycatechol is a lignan-derived phenol. It is an agonist of G protein-coupled receptor 35 (GPR35) with an EC50 value of 147 µM in a dynamic mass redistribution (DMR) assay using HT-29 cells. Dietary administration of 3-methoxycatechol (2%) alone, or in a model of multiorgan carcinogenesis induced by...