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Apoptosis can be induced when procaspase-3 is activated and converted to caspase-3. Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3. PAC-1's effectiveness was found to be directly proportional to the procaspase-3 concentration present in cells. In cancer cells, PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed.Formal Name: 4-(phenylmethyl)-1-piperazineacetic acid, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide. CAS Number: 315183-21-2. Synonyms: Procaspase-activating Compound 1. Molecular Formula: C23H28N4O2. Formula Weight: 392.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 283, 293, 328 nm. SMILES: C=CCc1cccc(/C=N\NC(=O)CN2CCN(CC2)Cc2ccccc2)c1O. InChi Code: InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+. InChi Key: YQNRVGJCPCNMKT-LFVJCYFKSA-N.
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