p38alpha MAPK-IN-1

p38alpha MAPK-IN-1 is an inhibitor of p38alpha MAPK (IC50 = 5,500 nM in a homogeneous time-resolved fluorescence (HTRF) assay). It inhibits TNF-alpha production induced by LPS in THP-1 cells (EC50 = 6,200 nM). p38alpha MAPK-IN-1 has been used in the study of p38alpha MAPK inhibitor binding interactions and kinetics.Formal Name: N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]phenyl]-urea. CAS Number: 443913-15-3. Synonyms: p38alpha MAPK Inhibitor 1, p38alpha Mitogen-activated Protein Kinase-IN-1, p38alpha Mitogen-activated Protein Kinase Inhibitor 1. Molecular Formula: C27H35N5O3. Formula Weight: 477.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Sparingly soluble: 1-10 mg/ml, DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=CC=C(C=C3)OCCN4CCOCC4. InChi Code: InChI=1S/C27H35N5O3/c1-20-5-9-22(10-6-20)32-25(19-24(30-32)27(2,3)4)29-26(33)28-21-7-11-23(12-8-21)35-18-15-31-13-16-34-17-14-31/h5-12,19H,13-18H2,1-4H3,(H2,28,29,33). InChi Key: FRZNJFWQVYAVCE-UHFFFAOYSA-N.