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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay34361-1 | 1 mg | - |
6 - 10 business days* |
635.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat... more
Product information "Orlistat-d3"
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat (Cay-10005426) by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase alpha (DAGLalpha), DAGLbeta, alpha/beta-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH, IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit fatty acid amide hydrolase (FAAH) or KIAA1363 (IC50s = >100 µM for both). Orlistat decreases ionomycin-induced production of the endocannabinoid 2-arachidonoyl glycerol (2-AG) in N18TG2 murine neuroblastoma cells when used at a concentration of 1 µM. It also inhibits fatty acid synthase (FASN, Ki = ~0.1 µM for the human enzyme) and the proliferation of PC3 prostate cancer cells in a concentration-dependent manner. Orlistat (10 mg/kg) decreases serum cholesterol levels and total body weight in a mouse model of obesity induced by a high-fat diet. Formulations containing orlistat have been used in the treatment of adult obesity.Formal Name: N-formyl-L-leucine-5,5,5-d3, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester. CAS Number: 1356930-46-5. Synonyms: (-)-Tetrahydrolipstatin-d3. Molecular Formula: C29H50D3NO5. Formula Weight: 498.8. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: [2H]C([2H])([2H])C(C)C[C@H](NC=O)C(O[C@@H](CCCCCCCCCCC)C[C@@H]1OC([C@H]1CCCCCC)=O)=O. InChi Code: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1/i3D3/t23?,24-,25-,26-,27-. InChi Key: AHLBNYSZXLDEJQ-HDVRVJOHSA-N.
Keywords: | (-)-Tetrahydrolipstatin-d3, N-formyl-L-leucine-5,5,5-d3, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 34361 |
Properties
Application: | GC-MS, LC-MS internal standard, quantification, pancreatic lipase inhibitor |
MW: | 498.8 D |
Formula: | C29H50D3NO5 |
Purity: | >99% deuterated forms (d1-d3) |
Format: | Solid |
Database Information
CAS : | 1356930-46-5| Matching products |
KEGG ID : | K14073 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H411 |
P Phrases: | P264, P270, P273, P301+310, P330, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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