Olmesartan Medoxomil-d6

Olmesartan medoxomil-d6 is intended for use as an internal standard for the quantification of olmesartan medoxomil (Cay-11614) by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan (Cay-23412), a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2 receptor. Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, when administered at a dose of 10 mg/kg per day, as well as in chow-fed control animals when administered at a dose of 11.4 mg/kg per day. Olmesartan medoxomil also inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats. Formulations containing olmesartan medoxomil have been used in the treatment of hypertension.Formal Name: 4-(1-hydroxy-1-methylethyl-d6)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester. CAS Number: 1127298-67-2. Molecular Formula: C29H24D6N6O6. Formula Weight: 564.6. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CCCC1=NC(C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])=C(C(OCC(O2)=C(C)OC2=O)=O)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3. InChi Code: InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)/i3D3,4D3. InChi Key: UQGKUQLKSCSZGY-LIJFRPJRSA-N.