NV-5138

NV-5138 is a sestrin modulator and mammalian target of rapamycin protein complex 1 (mTORC1) activator. It binds to sestrin 2 (Kd = 1.49 µM) and induces dissociation of sestrin 2 from the multimeric mTORC1 inhibitory complex GATOR2 and mTORC1 activation when used at concentrations ranging from 30 to 100 µM. NV-5138 (40, 80, or 160 mg/kg) reduces immobility time in the forced swim test and latency to feed in the novelty-suppressed feeding test, indicating antidepressant- and anxiolytic-like activity, respectively, in rats, effects that can be reversed by the mTORC1 inhibitor rapamycin (Cay-13346). It also reverses behavioral and synaptic deficits in a rat model of chronic stress-induced depression.Formal Name: 2S-amino-5,5-difluoro-4,4-dimethyl-pentanoic acid. CAS Number: 2095886-80-7. Molecular Formula: C7H13F2NO2. Formula Weight: 181.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10mM. SMILES: FC(F)C(C)(C)C[C@H](N)C(O)=O. InChi Code: InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1. InChi Key: HRFIMCJTDKEPPV-BYPYZUCNSA-N.