35 products were found matching "K20394"!

Description: Sestrin-2 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is P58004.

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. SESN2 antibody detects Sestrin 2, a stress-inducible metabolic regulator that protects cells from oxidative damage and maintains energy balance through AMPK and mTOR signaling. The UniProt recommended name is Sestrin 2 (SESN2). This...

NV-5138 is a sestrin modulator and mammalian target of rapamycin protein complex 1 (mTORC1) activator. It binds to sestrin 2 (Kd = 1.49 µM) and induces dissociation of sestrin 2 from the multimeric mTORC1 inhibitory complex GATOR2 and mTORC1 activation when used at concentrations ranging from 30 to 100 µM. NV-5138...

Human Sestrin2, also known as hypoxia induced gene 95 (GenBank Accession No. NM_031459), full length, a.a. 2-480(end), with N-terminal FLAG-tag, MW=55 kDa, expressed in Sf9 insect cells via a baculovirus expression system.Application: Useful for the stud

ELISA Type: Sandwich. Detection Range: 31.25-2000µg/mL. Sensitivity: 18.75µg/mL. Sample Types: Serum, Plasma. Protein function: Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25259925). In absence of leucine,...

Anti-SESTRIN2 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist, this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with...

Protein function: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684,...

Protein function: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse SESN2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse SESN2. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human SESN2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human SESN2. Next,...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SESN2. Antigen Species: Human